Ucwaningo lwefomu yekristalu yezidakamizwa kanye nokuhlola ukungaguquguquki

Ukuqapha ku-inthanethi kunikeza imiphumela esheshayo yokuhlolwa kwekristalu okuqondiwe, idatha eqhubekayo ikhuthaza izindlela zokusabela namaphoyinti okugcina, okunikeza ukwenziwa, izikhombisi-ndlela.

Izinhlobo ezahlukene zekristalu zomuthi ofanayo zingabonisa umehluko omkhulu ekubukekeni, ukuncibilika, indawo yokuncibilika, izinga lokuqedwa, i-bioavailability, njll., ngaleyo ndlela kuthinte ukuzinza, i-bioavailability, nokusebenza ngempumelelo komuthi.Ngakho-ke, kuyadingeka ukuqinisekisa ukuba khona kwefomu lekristalu elihlosiwe ngesikhathi sokuhlanganiswa kwezidakamizwa kanye nezinqubo zokwakhiwa.

Enqubweni yokukhiqiza umuthi omusha, kuyadingeka ukuqapha ngesikhathi sangempela ukwakheka kwesigaba sekristalu somuthi esixazululweni sokusabela kokuhlanganiswa.Lokhu kwenzelwa ukuthuthukisa inqubo nokuqinisekisa ukuthi isigaba sekristalu esiqondiwe somuthi siyahlanganiswa.I-Raman spectroscopy ingasetshenziselwa ukuqapha endaweni, ehlinzeka ngokuhlaziywa kwesikhathi sangempela kokwakheka kwesigaba sekristalu ekuphenduleni kokuhlanganiswa kwezidakamizwa, ikakhulukazi okulungele ukuhlaziya okuphelele kwezinhlelo eziqukethe i-polymorphic ne-amorphous API.

I-Raman spectroscopy eku-inthanethi iqondisa ukuhlolwa kwesigaba sekristalu ngezimo ezihlukahlukene zokusabela, njengoba kuboniswe ukuhlolwa kwenkampani eyenza imithi yamaqoqo okwakhiwa.Imiphumela iqinisekise ukuqondanisa nesithako esisebenzayo semithi, ekhombisa ucwaningo oluyimpumelelo.Imikhawulo yangaphambili kusetshenziswa i-XRD nezinye izisetshenziswa zelebhu iholele ekuvinjweni kwedatha kanye nemijikelezo yokuthuthukiswa enwetshiwe.Elinye icala liqokomise ukuhlukaniswa okuphumelelayo kwesikhathi sangempela sokuguqulwa kwesigaba sekristalu ezinqubweni eziyisithupha ezihlukene, okuhlinzeka ngemininingwane esheshayo emiphumeleni yomkhiqizo.